Food Allergy and Physiology: A Review Article

• Samahir Sabri Hamid

  College of Nursing, University of Basrah

Given the rising incidence of allergies, Proteins, either in their natural state or in forms arising from food preparation, are the source of food allergies. The field of proteomics has substantially benefited from advancements in mass spectrometry. These developments round out the range of biological assays that have been employed up to this point, including PCR and ELISA, and enable the identification and measurement of allergenic protein traces in complicated mixtures. We highlight significant advancements in mass-spectrometric techniques and examine approaches categorized based on their capacity to simultaneously quantify and detect allergenic proteins

Highlights:

1. Proteomics Advancements – Mass spectrometry improves allergen detection in food.
2. Diagnostic Methods – ELISA, PCR, and immunoassays enhance allergen identification.
3. Regulations – European laws mandate allergen labeling on food products.

Keywords: Food allergies, proteomics, mass spectrometry, ELISA, PCR

[1] C. Ortolani, M. Ispano, J. Scibilia, and E. Pastorello*, "Introducing chemists to food allergy," Allergy, vol. 56, pp. 5-8, 2001.

[2] R. S. Kagan, "Food allergy: an overview," Environmental health perspectives, vol. 111, pp. 223-225, 2003.

[3] A. M. Tiryag and H. H. Atiyah, "Nurses' knowledge toward obesity in al-Basra city," Annals of the Romanian Society for Cell Biology, vol. 25, pp. 4667-4673, 2021.

[4] T. A. Masoodi and G. Shafi, "Analysis of casein alpha S1 & S2 proteins from different mammalian species," Bioinformation, vol. 4, p. 430, 2010.

[5] G. Kanny, D.-A. Moneret-Vautrin, J. Flabbee, E. Beaudouin, M. Morisset, and F. Thevenin, "Population study of food allergy in France," Journal of Allergy and Clinical Immunology, vol. 108, pp. 133-140, 2001.

[6] R. Meyer, "Infant feeding in the first year. 1. Feeding practices in the first six months of life," J Fam Health Care, vol. 19, pp. 13-7, 2009.

[7] F. Bouteloup, "Organisation de l’Allergologie en France."

[8] A. M. Tiryag and H. H. Atiyah, "Nurses’ knowledge toward bariatric surgery at surgical wards at teaching hospitals in Al-Basra city," Indian Journal of Forensic Medicine & Toxicology, vol. 15, pp. 5152-5159, 2021.

[9] W. H. Organization, "Principles and Methods for Assessing Allergic Hypersensitization Associated with Exposure to Chemicals-Environmental Health Criteria 212."

[10] H. H. Abdul-Ra’aoof, A. M. Tiryag, and M. A. Atiyah, "Knowledge, attitudes, and practice of nursing students about insulin therapy: A cross-sectional study," Academia Open, vol. 9, pp. 10.21070/acopen. 9.2024. 8795-10.21070/acopen. 9.2024. 8795, 2024.

[11] T. K. Hervey and J. V. McHale, Health law and the European Union: Cambridge University Press, 2004.

[12] N. Coutrelis, "European Union food law update," J. Food L. & Pol'y, vol. 1, p. 493, 2005.

[13] H. H. Abdul-Ra’aoof, S. B. Dawood, F. A. Jassim, S. K. Jassim, S. S. Issa, A. M. Tiryag, et al., "Moderate proficiency in suture techniques among nurses: A cross-sectional study," Academia Open, vol. 9, 2024.

[14] T. K. Hervey and J. V. McHale, "Law, health and the European Union," Legal Studies, vol. 25, pp. 228-259, 2005.

[15] I. Zainel, H. Abdul-Ra'aoof, and A. Tiryag, "Mothers' knowledge and attitudes towards her children with neonatal jaundice: A cross-sectional study," Health Education and Health Promotion, vol. 10, pp. 565-570, 2022.

[16] L. Monaci and A. Visconti, "Mass spectrometry-based proteomics methods for analysis of food allergens," TrAC Trends in Analytical Chemistry, vol. 28, pp. 581-591, 2009.

[17] H. Abdul-Ra’aoof, M. Akber, F. Jassim, A. Tiryag, S. Issa, M. Atiyah, et al., "The psychological impact of violence on emergency department and intensive care unit nurses: A cross-sectional study," Research Journal of Trauma and Disability Studies, vol. 3, pp. 228-233, 2024.

[18] R. Poms, C. Klein, and E. Anklam, "Methods for allergen analysis in food: a review," Food additives and contaminants, vol. 21, pp. 1-31, 2004.

[19] E. H. Rahi, Z. M. H. Al-Hejaj, and A. M. Tiryag, "Nurses' knowledge of nonalcoholic fatty liver disease: A cross-sectional study," Academia Open, vol. 9, pp. 10.21070/acopen. 9.2024. 10306-10.21070/acopen. 9.2024. 10306, 2024.

[20] D. Y. Leung, "Molecular basis of allergic diseases," Molecular genetics and metabolism, vol. 63, pp. 157-167, 1998.

[21] H. A. Sampson, "Food allergy. Part 1: immunopathogenesis and clinical disorders," Journal of Allergy and Clinical Immunology, vol. 103, pp. 717-728, 1999.

[22] S. Kirsch, S. Fourdrilis, R. Dobson, M.-L. Scipio, G. Maghuin-Rogister, and E. De Pauw, "Quantitative methods for food allergens: a review," Analytical and bioanalytical chemistry, vol. 395, pp. 57-67, 2009.

[23] A. Tiryag, "Revitalizing hearts: The transformative impact of pacemaker therapy on cardiac conduction disorders," Academia Open, vol. 9, pp. 10-21070, 2024.

[24] A. Tiryag, M. Atiyah, and A. Khudhair, "Nurses' knowledge and attitudes toward thyroidectomy: A cross-sectional study," Health Education and Health Promotion, vol. 10, pp. 459-465, 2022.

[25] S. Ben Rejeb, M. Abbott, D. Davies, C. Cléroux, and P. Delahaut, "Multi-allergen screening immunoassay for the detection of protein markers of peanut and four tree nuts in chocolate," Food additives and contaminants, vol. 22, pp. 709-715, 2005.

[26] H. M. Sabty, S. B. Dawood, and A. M. Tiryag, "Nurses’ knowledge and practices on influenza vaccination for pregnant women," Jurnal Kebidanan Midwiferia, vol. 10, pp. 50-59, 2024.

[27] M. Careri, L. Elviri, A. Mangia, and C. Mucchino, "ICP-MS as a novel detection system for quantitative element-tagged immunoassay of hidden peanut allergens in foods," Analytical and bioanalytical chemistry, vol. 387, pp. 1851-1854, 2007.

[28] M. Akber, A. Tiryag, and A. Alobaidi, "Nurses’ knowledge regarding cast complications of limb fractures: A cross-sectional study," Central Asian Journal of Medical and Natural Science, vol. 5, pp. 195-200, 2024.

[29] R. E. Poms, E. Anklam, and M. Kuhn, "Polymerase chain reaction techniques for food allergen detection," Journal of AOAC International, vol. 87, pp. 1391-1397, 2004.

[30] M. A. Akber, A. M. Tiryag, and A. Alobaidi, "Nurses’ knowledge concerning developmental dysplasia of the hip: A cross-sectional study," American Journal of Pediatric Medicine and Health Sciences, vol. 2, pp. 155-160, 2024.

[31] T. Hirao, M. Hiramoto, S. Imai, and H. Kato, "A novel PCR method for quantification of buckwheat by using a unique internal standard material," Journal of Food Protection, vol. 69, pp. 2478-2486, 2006.

[32] A. M. Tiryag, S. B. Dawood, and S. K. Jassim, "Nurses’ knowledge and attitudes about enteral feeding complications by nasogastric tube in intensive care units," Rawal Medical Journal, vol. 48, pp. 689-693, 2023.

[33] S. Fremont, G. Kanny, S. Bieber, J. Nicolas, and D. Moneret‐Vautrin, "Identification of a masked allergen, α‐lactalbumin, in baby‐food cereal flour guaranteed free of cow's milk protein," Allergy, vol. 51, pp. 749-754, 1996.

[34] S. J. Koppelman, A. C. Knulst, W. J. Koers, A. H. Penninks, H. Peppelman, R. Vlooswijk, et al., "Comparison of different immunochemical methods for the detection and quantification of hazelnut proteins in food products," Journal of Immunological Methods, vol. 229, pp. 107-120, 1999.

[35] M. A. Mohammad, H. H. Abdul-Ra’aoof, K. A. Razzaq Manahi, and A. M. Tiryag, "Parents’ Knowledge and Attitudes toward Testicular Torsion," Bahrain Medical Bulletin, vol. 46, 2024.

[36] B. W. Blais, M. Gaudreault, and L. M. Phillippe, "Multiplex enzyme immunoassay system for the simultaneous detection of multiple allergens in foods," Food Control, vol. 14, pp. 43-47, 2003.

[37] M. Jabbar, M. Mohammad, and A. Tiryag, "Changes in male reproductive hormones in patients with COVID-19," Georgian Medical News, vol. 342, pp. 42-46, 2023.

[38] B. Scheibe, W. Weiss, F. Ruëff, B. Przybilla, and A. Görg, "Detection of trace amounts of hidden allergens: hazelnut and almond proteins in chocolate," Journal of Chromatography B: Biomedical Sciences and Applications, vol. 756, pp. 229-237, 2001.

[39] M. A. Mohammad, A. Y. Al-Timary, and A. M. Tiryag, "Safety of Tubeless Double Access Percutaneous Nephrolithotomy Compared to Single Access Approach," Bahrain Medical Bulletin, vol. 45, 2023.

[40] R. Yamanishi, K. Kondo, H. Tsuji, and T. Ogawa, "Micro-assay to measure the allergenicity of a Kunitz-type soybean trypsin inhibitor toward Balb/c mice by using RBL-2H3 cells," Bioscience, biotechnology, and biochemistry, vol. 59, pp. 1272-1275, 1995.

[41] R. Yamanishi, H. Tsuji, N. Bando, I. Yoshimoto, and T. Ogawa, "Micro-assay method for evaluating the allergenicity of the major soybean allergen, Gly m Bd 30K, with mouse antiserum and RBL-2H3 cells," Bioscience, biotechnology, and biochemistry, vol. 61, pp. 19-23, 1997.

[42] A. A. A. Al-Iedan, M. A. Akber, S. B. Dawood, A. I. H. Alobaidi, S. S. Issa, H. H. A. Raaoof, et al., "Bridging the gap: Enhancing open fracture care in emergency nursing," Academia Open, vol. 9, pp. 10.21070/acopen. 9.2024. 8847-10.21070/acopen. 9.2024. 8847, 2024.

[43] S. Kaul, D. Lüttkopf, B. Kastner, L. Vogel, G. Höltz, S. Vieths, et al., "Mediator release assays based on human or murine immunoglobulin E in allergen standardization," Clinical & Experimental Allergy, vol. 37, pp. 141-150, 2007.

[44] M. Mohammad, F. Jassim, and A. Tiryag, "Retrograde Intrarenal Lithotripsy Using Disposable Flexible Ureteroscope," Georgian Medical News, vol. 348, pp. 44-46, 2024.

[45] M. L. Sanz, J. Maselli, P. Gamboa, A. Oehling, I. Dieguez, and A. De Weck, "Flow cytometric basophil activation test: a review," Journal of Investigational Allergology & Clinical Immunology, vol. 12, pp. 143-154, 2002.

[46] A. De Weck, M. Sanz, P. Gamboa, W. Aberer, J. Bienvenu, M. Blanca, et al., "Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls," International archives of allergy and immunology, vol. 146, pp. 177-189, 2008.

[47] D. Ebo, C. Bridts, M. Hagendorens, N. Aerts, L. De Clerck, and W. Stevens, "Basophil activation test by flow cytometry: present and future applications in allergology," Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology, vol. 74, pp. 201-210, 2008.

[48] M. A. Mohammad, F. A. Jassim, and A. M. Tiryag, "Single-use flexible ureteroscope for the treatment of a renal stone," Revista Latinoamericana de Hipertension, vol. 18, 2023.

[49] D. A. Moneret-Vautrin, J. Sainte-Laudy, G. Kanny, and S. Frémont, "Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy," Annals of Allergy, Asthma & Immunology, vol. 82, pp. 33-40, 1999.

[50] D. G. Ebo, M. M. Hagendorens, C. H. Bridts, A. J. Schuerwegh, L. S. De Clerck, and W. J. Stevens, "Flow cytometric analysis of in vitro activated basophils, specific IgE and skin tests in the diagnosis of pollen‐associated food allergy," Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology, vol. 64, pp. 28-33, 2005.

[51] Z. S. Dawood, K. M. Jassim, A. M. Tiryag, and A. S. Khudhair, "Nurses' Knowledge and Attitudes Toward Deep Vein Thrombosis: A Cross-Sectional Study," Bahrain Medical Bulletin, vol. 45, 2023.

[52] M. Worm, S. Hompes, E. M. Fiedler, A. K. Illner, T. Zuberbier, and S. Vieths, "Impact of native, heat‐processed and encapsulated hazelnuts on the allergic response in hazelnut‐allergic patients," Clinical & Experimental Allergy, vol. 39, pp. 159-166, 2009.

[53] M. F. Hasan, W. F. Hussein, A. M. Tiryag, I. J. Ali, and Z. M. Shaker, "Nurses’ knowledge toward lower back pain: A cross-sectional study," Academia Open, vol. 9, pp. 10.21070/acopen. 9.2024. 10363-10.21070/acopen. 9.2024. 10363, 2024.