Association between Blood Sugar, Methyl-paraben, and Albumin Concentrations in Women with Hyperglycemic

Hubungan antara Gula Darah, Metil-paraben, dan Konsentrasi Albumin pada Wanita dengan Hiperglikemik

Authors

  • Lamiah Mohseen Alivi Jesas Ministry of Education, Thi-Qar Education Directorate, 64001
  • Nasim Hayati Ministry of Education, Thi-Qar Education Directorate, 64001
  • Fatemeh Davoodi Ministry of Education, Thi-Qar Education Directorate, 64001

Keywords:

Type 2 Diabetes, Methyl Paraben, Albumin, Iranian Women, Blood Sugar

Abstract

Background: Type 2 diabetes is a type of metabolic disorder, and the role of parabens as endocrine-disrupting chemicals in the physiological process of diabetes and their effects on the function of serum albumin has always been a scientific paradox. Until now, there is little information about the correlation between parabens and sugar level of diabetic people as well as their effect on albumin concentration in Iranian society, which has been investigated as the most important objective of this research. Aim of Study: The study aimed to investigation the relationship between blood sugar, methyl-paraben, and albumin diabetic Women. Material and Method: 200 diabetic patients and 75 control were subjected to laboratory tests. Demographic data were prepared and analyzed. The concentration of methyl paraben and albumin were statistically analyzed. The results: The demographic data showed that there is a significant relationship between the diabetic group and the control in the age factor and body mass index (P=0.012). The analysis of laboratory data showed that there was no significant relationship between blood sugar concentration and albumin (P=0.577) and between blood sugar concentration and methyl paraben concentration (P=0.532). Furthermore, the statistical test showed that there was no significant relationship between the concentration of albumin and the concentration of methyl paraben (P=0.374). Conclusion: The results of this research show that there is no statistical relationship between the concentrations of FBS, methyl paraben and albumin, which can be the result of genetic diversity in the Iranian diabetic community with other populations in different parts of the world.

Highlights:

  • No significant correlation was found between blood sugar, methyl paraben, and albumin levels in Iranian diabetic women.
  • Demographic factors such as age and body mass index showed a significant association with diabetes risk.
  • Statistical tests confirmed non-normal data distribution and absence of meaningful correlations among the three studied biomarkers.

Keywords: Type 2 Diabetes, Methyl Paraben, Albumin, Iranian Women, Blood Sugar

References

[1] N. Mukherjee and S. K. Chaturvedi, “Depressive Symptoms and Disorders in Type 2 Diabetes Mellitus,” World Journal of Diabetes, vol. 32, no. 5, pp. 142, 2019. DOI: 10.4239/wjd.v10.i5.142.

[2] E. Of, D. Mellitus, and U. Diabetes, “World Journal of Pharmaceutical Research,” World Journal of Pharmaceutical Research, vol. 12, no. 9, pp. 162–169, 2023. DOI: 10.20959/wjpr20239-50652.

[3] Y. Zheng, S. H. Ley, and F. B. Hu, “Global Aetiology and Epidemiology of Type 2 Diabetes Mellitus and Its Complications,” Nature Reviews Endocrinology, vol. 14, pp. 88–98, 2018. DOI: 10.1038/nrendo.2017.151.

[4] K. Nowak, W. R. Wrona, M. Górska, and E. Jabłońska, “Parabens and Their Effects on the Endocrine System,” Molecular and Cellular Endocrinology, 2018. DOI: 10.1016/j.mce.2018.03.014.

[5] L. K. Sosvorova and J. Vitku, “Parabens and Their Relation to Obesity,” Physiology Research, Apr. 2020.

[6] J. Chen, E. M. Hartmann, K. Van Den Wymelenberg, and R. U. Halden, “Assessment of Human Exposure to Triclocarban, Triclosan, and Five Parabens in U.S. Indoor Dust,” Environmental Pollution, vol. 360, pp. 623–630, May 2018. DOI: 10.1016/j.envpol.2018.06.058.

[7] M. Chen, B. Yu, Z. Zhang, and W. Ma, “Occurrence of Parabens in Outdoor Environments: Implications for Human Exposure Assessment,” Environmental Pollution, vol. 282, 2021. DOI: 10.1016/j.envpol.2021.117075.

[8] A. V. Marta-Sanchez et al., “Trace Analysis of Parabens Preservatives in Water Samples,” Environmental Science and Pollution Research, vol. 1694, 2018. DOI: 10.1007/s11356-018-1651-2.

[9] F. Fransway et al., “Paraben Toxicology,” Journal of Clinical and Aesthetic Dermatology, vol. 30, no. 1, 2019.

[10] D. Alwadi, Q. Felty, R. A. Roy, C. Yoo, and A. Deoraj, “Environmental Phenol and Paraben Exposure Risks,” International Journal of Environmental Research and Public Health, vol. 19, no. 9, 2022. DOI: 10.3390/ijerph19092683.

[11] D. A. Belinskaia and N. V. Goncharov, “Theoretical and Practical Aspects of Albumin Esterase Activity,” Russian Journal of Bioorganic Chemistry, vol. 46, no. 3, pp. 287–298, 2020. DOI: 10.1134/S1068162018030097.

[12] J. C. Bae et al., “Association Between Serum Albumin, Insulin Resistance, and Diabetes,” Diabetes & Metabolism, vol. 39, pp. 26–32, 2013. DOI: 10.1016/j.diabet.2013.01.002.

[13] D. A. Belinskaia et al., “Serum Albumin in Health and Disease,” International Journal of Molecular Sciences, 2021.

[14] D. A. Belinskaia et al., “Esterase Activity of Serum Albumin by 1H NMR,” International Journal of Molecular Sciences, 2021.

[15] S. G. Khader and H. F. Okab, “Assessment of Glucose Metabolism in Thalassemia Patients,” International Journal of Health Sciences, vol. 6, no. S8, pp. 2929–2935, 2018.

[16] J. Adailton et al., “Diagnosis of Diabetes Mellitus and Living with a Chronic Condition,” BMC Public Health, 2018, pp. 1–8.

[17] D. Dorota, B. Gromadzi, and W. Wojciech, “Parabens: From Environmental Studies to Human Health,” Environmental Toxicology and Pharmacology, vol. 67, pp. 27–42, 2019.

[18] K. Nowak, W. R. Wrona, M. Górska, and E. Jabłońska, “Parabens and Their Effects on the Endocrine System,” Molecular and Cellular Endocrinology, 2018. DOI: 10.1016/j.mce.2018.03.014.

[19] R. Golden and J. Gandy, “A Review of the Endocrine Activity of Parabens,” Environmental Health Perspectives, pp. 435–458, 2005. DOI: 10.1289/ehp.7720.

[20] A. F. Fransway et al., “Paraben Toxicology,” Journal of Clinical and Aesthetic Dermatology, vol. 30, no. 1, 2019.

[21] S. Ali, Q. Alkafajy, and R. A. Abdul-Jabbar, “Comprehensive Effects of Parabens in Human Physiology,” Biomedicine & Pharmacotherapy, May 2021.

[22] V. M. Rosenoer, “Clinical Aspects of Albumin Metabolism,” in Albumin Structure, Function and Uses, Pergamon Press, pp. 345–367. DOI: 10.1016/B978-0-08-019603-9.50023-5.

[23] D. A. Belinskaia et al., “Serum Albumin in Health and Disease,” International Journal of Molecular Sciences, 2021.

[24] L. K. Sosvorova and J. Vitku, “Parabens and Their Relation to Obesity,” Physiology Research, Apr. 2020.

[25] A. Guerin-Dubourg, A. Catan, E. Bourdon, and P. Rondeau, “Structural Modifications of Human Albumin in Diabetes,” Diabetes & Metabolism, vol. 38, no. 2, pp. 171–178, 2012. DOI: 10.1016/j.diabet.2011.11.002.

[26] A. Bahar et al., “Correlation Between Prediabetes Conditions and Microalbuminuria,” Journal of Diabetes Research, vol. 5, no. 2, 2013.

[27] X. Feng et al., “Influence of Serum Albumin on HbA1c and Glycemic Status,” Diabetes, vol. 8, no. 1, pp. 1–10, 2021. DOI: 10.3390/diabetes8010001.

[28] D. C. Chang et al., “Reduced Plasma Albumin Predicts Type 2 Diabetes,” Diabetology & Metabolic Syndrome, vol. 11, no. 14, 2019. DOI: 10.1186/s13098-019-0409-y.

[29] J. E. Jun et al., “Increase in Serum Albumin and Progression to Diabetes,” Journal of Diabetes, vol. 11, no. 4, pp. 1–13, 2017. DOI: 10.1111/1753-0407.12609.

[30] A. Khoundabi, A. Kazemnejad, and M. Mansourian, “Factors Associated with Serum Albumin in Type 2 Diabetes,” Journal of Diabetes, vol. 18, no. 1, pp. 1–6, 2016. DOI: 10.1111/1753-0407.12428.

[31] Y. Hajizadeh, G. K. Feizabadi, and A. Feizi, “Parabens in Urine and Care Product Use in Iranian Adults,” International Journal of Environmental Health Research, vol. 30, no. 00, pp. 1–17, 2020. DOI: 10.1080/09603123.2020.1798362.

[32] S. Fadaei and H. Pourzamani, “Association of Maternal Urinary Parabens and Neonatal Indices,” Journal of Environmental Health Science & Engineering, 2020.

[33] W. Huo et al., “Urinary Parabens and Gestational Diabetes,” Environmental Research, vol. 2018. DOI: 10.1016/j.envres.2018.12.028.

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Published

2025-07-03

How to Cite

Jesas, L. M. A., Hayati, N., & Davoodi, F. (2025). Association between Blood Sugar, Methyl-paraben, and Albumin Concentrations in Women with Hyperglycemic: Hubungan antara Gula Darah, Metil-paraben, dan Konsentrasi Albumin pada Wanita dengan Hiperglikemik. Indonesian Journal on Health Science and Medicine, 2(1), 10.21070/ijhsm.v2i1.187. Retrieved from https://ijhsm.umsida.ac.id/index.php/ijhsm/article/view/187

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