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Section Articles

Assessment of Selected Physiological and Immunological Parameters in a Sample of Obese Patients in Samarra City

Vol. 2 No. 2 (2025): Oktober:
DOI : https://doi.org/10.21070/ijhsm.v2i2.263
Published : Sep 29, 2025

Khalida Khaleel Abdullah (1), Hadeer Hussein Alwan (2), Asmaa Ismael Hussein (3), Saif al deen Mamdoh Khatlan (4)

(1) Department of Biology College of Education University of Samarra, Iraq
(2) Department of Biology College of Education University of Samarra, Iraq
(3) Department of Biology College of Education University of Samarra, Iraq
(4) Department of Biology College of Education for women University of Kirkuk, Iraq
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Abstract:

The present study was conducted to assess the hormone's levels (nesfatin-1, leptin, resistin and adiponectin) on some of inflammatory cytokines or the so-called adipokines which exert a variety of biological activities (tumor necrosis factor alpha: TNF-α and interleukin-6 IL6), as well as BMI & lipid profile in serum of obese women in Samarra 10. The present study had included (50) samples, and they were divided into: 25 samples of obese women age ranged between (25-45) years, and (25) samples for the control group that constituted from women with normal weight. The results of the study demonstrated a marked elevation in the levels of leptin and resistin hormonal levels, inflammatory cytokines, i.e., tumor necrosis factor-α (TNF-α) interleukin -6 (IL-6), lipid profile evaluated by body mass index ) as well as significant decline in nesfatin-1 and adiponectin at the significance level represented by mean± SD: (P≤0.05) among obese women compared with control group.


Highlights:



  1. Obese women showed significantly higher serum levels of leptin, resistin, TNF-α, IL-6, and lipid profile abnormalities compared to controls.

  2. Nesfatin-1 and adiponectin levels were markedly reduced in obese patients, indicating impaired appetite regulation and anti-inflammatory response.

  3. Findings confirm obesity as a state of chronic low-grade inflammation, linking it to increased risk of diabetes and cardiovascular disease.

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