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Section Articles

Evaluation Of TNF And IL6 In Patient with Metabolic Syndrome

Vol. 2 No. 3 (2025): Desember:
DOI : https://doi.org/10.21070/ijhsm.v2i3.337
Published : Dec 16, 2025

Nawras Abdel Abbas Esmaeel (1)

(1) Technical College of Health and Medical Science, Babylon, Department of medical Rehabilitation and physiotherapy Techniques, Iraq
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Abstract:

General background: Metabolic syndrome (MetS) represents a clustering of cardiovascular risk factors characterized by visceral adiposity, insulin resistance, and dyslipidemia, with chronic low-grade inflammation playing a central pathophysiological role. Specific Background: Proinflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), have been implicated in MetS pathogenesis through their effects on insulin signaling and endothelial function. Knowledge Gap: However, the precise inflammatory profile alterations in MetS patients within the Iraqi population remain inadequately characterized. Aims: This case-control study evaluated serum TNF-α and IL-6 concentrations in 45 MetS patients compared with 45 healthy controls in Thi-Qar, Iraq, alongside metabolic parameters including fasting blood sugar (FBS), lipid profiles, and blood pressure measurements. Results: Patients demonstrated significantly elevated body mass index and waist circumference compared to controls. Furthermore, FBS, total cholesterol, triglycerides, systolic and diastolic blood pressure showed significant differences between groups, while HDL-cholesterol remained comparable. Notably, both IL-6 and TNF-α levels were significantly reduced in MetS patients relative to controls. Novelty: These findings challenge conventional understanding by demonstrating decreased rather than elevated proinflammatory cytokine concentrations in MetS. Implications: The results suggest complex inflammatory regulatory mechanisms in MetS that warrant further mechanistic investigation to inform targeted therapeutic interventions.
Highlight :




  • Inflammation in MetS: IL-6 and TNF-α levels differ significantly between MetS patients and controls.




  • Metabolic Characteristics: MetS patients show higher BMI, WC, FBS, TG, and blood pressure, with no significant HDL difference.




  • Pathophysiological Role: Chronic low-grade inflammation is closely linked to metabolic syndrome development.




Keywords : Metabolic syndrome, TNF-α, IL-6, Inflammation, Thi-Qar

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