Estimation the Correlation between Heavy Metals and Oxidative Stress in People Living Near Incineration in Al-Nasr City in Thi-qar Governorate
Estimasi Korelasi antara Logam Berat dan Stres Oksidatif pada Orang yang Tinggal di Dekat Insinerasi di Kota Al-Nasr di Kegubernuran Thi-qar
DOI:
https://doi.org/10.21070/ijhsm.v1i2.41Keywords:
Oxidative stress, Lead, Cadmium, Zinc, Glutathione, AlbuminAbstract
Abstract. Background: The current study is a prospective research. Some laboratory tests were done on people living near incineration in Al-Nasr city in thi-qar governorate. This scientific study has its goal as providing social benefits through supporting and augmenting the efforts of Environmental Authority in their work of organizing and monitoring waste disposal processes, with due consideration to the health status of these individuals to help decrease the incidence of waste burning besides finding safe solutions for waste disposal. Methods: The samples were collected from people living near incineration in Al-Nasr city in Thi-Qar governorate. Seventy five samples of blood obtained from subjects residing near incineration, and seventy five samples also obtained from normal individuals as a control group, subject's age ranged between (20-60) years, during the period from October 2022 up to April 2023. Serum levels were assayed for lead (Pb), cadmium (Cd), zinc (Zn), malondialdehyde (MDA), Glutathione (GSH) and albumin (Alb). Results: A highly significant increase in serum Pb, serum Cd, serum Zn, and serum MDA in people living near incineration as compared to the control group was observed. A significant decrease in serum GSH, and serum Alb in people living near incineration as compared to the controls group was found. The study reported a positive correlation between Pb and (Cd, Zn, MDA) while it reported a negative correlation between Pb and (GSH, Alb).
Highlights:
- Prospective study on health impacts of incineration in Al-Nasr city.
- Blood tests on 75 residents, 75 controls; analyzed Pb, Cd, Zn, MDA, GSH, Alb.
- Increased Pb, Cd, Zn, MDA; decreased GSH, Alb; correlations observed.
Keywords: Oxidative stress, Lead, Cadmium, Zinc, Glutathione, Albumin
References
Committee on Health Effects of Waste Incineration, "Waste Incineration and Public Health," The National Academies Press, Washington, D.C., USA, 2000, pp. 17–32.
J. F. Perrot and A. Subiantoro, "Municipal Waste Management Strategy Review and Waste-to-Energy Potentials in New Zealand," Sustainability (Basel), vol. 10, no. 9, p. 3114, 2018.
D. Porta, S. Milani, A. I. Lazzarino, C. A. Perucci, and F. Forastiere, "Systematic Review of Epidemiological Studies on Health Effects Associated with Management of Solid Waste," Environmental Health, vol. 8, no. 1, p. 60, 2009.
E. de Titto and A. Savino, "Environmental and Health Risks Related to Waste Incineration," Waste Management Research, vol. 37, no. 10, pp. 976–986, 2019.
S. W. Hu and C. M. Shy, "Health Effects of Waste Incineration: A Review of Epidemiologic Studies," Journal of the Air & Waste Management Association, vol. 51, no. 7, pp. 1100–1109, 2001.
A. Ranzi, V. Fano, L. Erspamer, P. Lauriola, C. A. Perucci, and F. Forastiere, "Mortality and Morbidity Among People Living Close to Incinerators: A Cohort Study Based on Dispersion Modeling for Exposure Assessment," Environmental Health, vol. 10, no. 1, p. 22, 2011.
Y. Fukuda, K. Nakamura, and T. Takano, "Dioxins Released from Incineration Plants and Mortality from Major Diseases: An Analysis of Statistical Data by Municipalities," Journal of Medical and Dental Sciences, vol. 50, no. 4, pp. 249–255, 2003.
S. Candela, A. Ranzi, L. Bonvicini, F. Baldacchini, P. Marzaroli, and A. Evangelista, et al., "Air Pollution from Incinerators and Reproductive Outcomes: A Multisite Study," Epidemiology, vol. 24, no. 6, pp. 863–870, 2013.
P. Zambon, P. Ricci, E. Bovo, A. Casula, M. Gattolin, and A. R. Fiore, et al., "Sarcoma Risk and Dioxin Emissions from Incinerators and Industrial Plants: A Population-Based Case-Control Study (Italy)," Environmental Health, vol. 6, no. 1, p. 19, 2007.
P. Comba, V. Ascoli, S. Belli, M. Benedetti, L. Gatti, and P. Ricci, et al., "Risk of Soft Tissue Sarcomas and Residence in the Neighbourhood of an Incinerator of Industrial Wastes," Occupational and Environmental Medicine, vol. 60, no. 9, pp. 680–683, 2003.
N. Floret, F. Mauny, B. Challier, P. Arveux, J. Y. Cahn, and J. F. Viel, "Dioxin Emissions from a Solid Waste Incinerator and Risk of Non-Hodgkin Lymphoma," Epidemiology, vol. 14, no. 4, pp. 392–398, 2003.
J. F. Viel, C. Daniau, S. Goria, P. Fabre, P. de Crouy-Chanel, and E. A. Sauleau, et al., "Risk for Non-Hodgkin’s Lymphoma in the Vicinity of French Municipal Solid Waste Incinerators," Environmental Health, vol. 7, no. 1, p. 51, 2008.
S. Y. Eom, B. Lee, S. Hong, Y. S. Hong, K. H. Choi, and H. J. Kwon, et al., "Exposure to Hazardous Substances and Their Health Effects Among Residents Living Near Three Industrial Waste Incinerators in Korea," Journal of Korean Medical Science, vol. 38, no. 37, p. e289, 2023.
J. H. Kim and J. C. Kang, "Effects of Sub-Chronic Exposure to Lead (Pb) and Ascorbic Acid in Juvenile Rockfish: Antioxidant Responses, MT Gene Expression, and Neurotransmitters," Chemosphere, vol. 171, pp. 520–527, 2017.
J. W. Lee, et al., "Toxic Effects of Lead Exposure on Bioaccumulation, Oxidative Stress, Neurotoxicity, and Immune Responses in Fish: A Review," Environmental Toxicology and Pharmacology, vol. 68, pp. 101–108, 2019.
A. P. Neal, "Mechanisms of Heavy Metal Neurotoxicity: Lead and Manganese," Journal of Drug Metabolism and Toxicology, vol. 6, 2015.
N. Z. Shaban, S. E. Abd El-Kader, and F. A. K. Mogahed, et al., "Synergistic Protective Effect of Beta Vulgaris with Meso-2,3-Dimercaptosuccinic Acid Against Lead-Induced Neurotoxicity in Male Rats," Scientific Reports, vol. 11, p. 252, 2021.
B. Killian, T. H. Yuan, C. H. Tsai, T. H. T. Chiu, Y. H. Chen, and C. C. Chan, "Emission-Related Heavy Metal Associated with Oxidative Stress in Children: Effect of Antioxidant Intake," International Journal of Environmental Research and Public Health, vol. 17, no. 11, p. 3920, 2020.
T. Finkel and N. J. Holbrook, "Oxidants, Oxidative Stress and the Biology of Ageing," Nature, vol. 408, pp. 239–247, 2000.
A. K. Zaid and S. A. Sayer, "Association of Abnormal Levels of Serum Interleukin-33, Interleukin-23 with Oxidant-Antioxidants Status in Patients with Acute Liver Failure," Journal of Scientific Innovation, vol. 9, pp. 94–99, 2022.
K. L. Fong, P. B. McCay, J. L. Poyer, B. B. Keele, and H. Misra, "Evidence that Peroxidation of Lysosomal Membranes is Initiated by Hydroxyl Free Radicals Produced During Flavin Enzyme Activity," Journal of Biological Chemistry, vol. 248, no. 22, pp. 7792–7797, 1973.
E. Wills, "Role of Fatty Acid in the Pathogenesis of Insulin Resistance and NIDDM," Biological Chemistry Journal, vol. 113, no. 1, p. 315, 1969.
G. L. Ellman, "Tissue Sulfhydryl Groups," Archives of Biochemistry and Biophysics, vol. 82, pp. 70–77, 1959.
D. Webster, "Role of Oxidative Stress in Diabetic Complication," Clinical Chemistry Journal, vol. 53, p. 109, 1974.
A. Ebadi Torkayesh, F. Fathipoir, and M. Saidi-Mehrabd, "Entropy-Based Multi-Criteria Analysis of Thermochemical Conversions for Energy Recovery from Municipal Solid Waste Using Fuzzy VIKOR and ELECTRE III: Case of Azerbaijan Region, Iran," Journal of Energy Management Technology, vol. 3, pp. 17–29, 2019.
J. Torkashvand, et al., "Preparation of a Cellulose Acetate Membrane Using Cigarette Butt Recycling and Investigation of Its Efficiency in Removing Heavy Metals from Aqueous Solution," Scientific Reports, vol. 12, p. 20336, 2022.
H. Mohammadi, M. Morovati, Z. Zardosht, and G. Hassani, "Assessment of Uncontrolled PAHs Leakage from Littered Cigarette Butts into the Urban Environment," International Journal of Environmental Analytical Chemistry, 2023.
D. Dutta et al., "A Review on Recovery Processes of Metals from E-Waste: A Green Perspective," Science of the Total Environment, vol. 859, p. 160391, 2023.
A. Hossaini Motlagh et al., "Quality Variations of Leachate Resulting from Cigarette Filter Recycling as a Challenge for Its Management," Scientific Reports, vol. 14, p. 972, 2024.
J. Torkashvand et al., "Airborne Particulate Matter in Tehran’s Ambient Air," Journal of Environmental Health Science and Engineering, vol. 19, pp. 1179–1191, 2021.
J. Torkashvand et al., "The Potential Osteoporosis Due to Exposure to Particulate Matter in Ambient Air: Mechanisms and Preventive Methods," Journal of the Air and Waste Management Association, vol. 72, pp. 925–934, 2022.
C. S. Chen, T. H. Yuan, R. H. Shie, K. Y. Wu, and C. C. Chan, "Linking Sources to Early Effects by Profiling Urine Metabolome of Residents Living Near Oil Refineries and Coal-Fired Power Plants," Environmental International, vol. 102, pp. 87–96, 2017.
B. Killian, T. H. Yuan, C. H. Tsai, T. H. T. Chiu, Y. H. Chen, and C. C. Chan, "Emission-Related Heavy Metal Associated with Oxidative Stress in Children: Effect of Antioxidant Intake," International Journal of Environmental Research and Public Health, vol. 17, no. 11, p. 3920, Jun. 2020.
E. O. Olufunmilayo, M. B. Gerke-Duncan, and R. M. D. Holsinger, "Oxidative Stress and Antioxidants in Neurodegenerative Disorders," Antioxidants, vol. 12, no. 2, p. 517, 2023.
