Analysis of Alkaline Phosphatase (ALP) and Gamma Glutamyl Transferase (GGT) Levels in Adolescents Who Consume Alcoholic Beverages

• Octaviani Nindi Wulandari

  Program Studi D-IV Teknologi Laboratorium Medis, Universitas Muhammadiyah Sidoarjo

• Andika Aliviameita

  Program Studi D-IV Teknologi Laboratorium Medis, Universitas Muhammadiyah Sidoarjo

General Background: Excessive alcohol consumption can cause organ damage, particularly liver disorders, while Alkaline Phosphatase (ALP) and Gamma-glutamyltransferase (GGT) are enzymes used in the assessment of liver conditions. Specific Background: Alcohol consumption may be associated with changes in ALP and GGT levels, including variations related to the duration of alcohol consumption. Knowledge Gap: The study addresses the comparison of ALP and GGT levels between adolescents consuming alcohol for 1–3 years and those consuming alcohol for >3–5 years. Aims: This study aimed to analyze differences in ALP and GGT levels among adolescents consuming alcoholic beverages according to consumption duration. Results: This quantitative laboratory experimental study involved 30 male adolescents aged 18–24 years, with 15 respondents consuming alcohol for 1–3 years and 15 respondents for >3–5 years. Serum ALP and GGT were examined using the Kinetic-IFCC method with a Microlab 300 photometer. The mean ALP levels were 186.8 ± 43.7 U/L and 201.1 ± 42.2 U/L, while the mean GGT levels were 16.4 ± 6.8 U/L and 18.4 ± 9.9 U/L, respectively. Independent Samples T-Test results indicated no significant difference in ALP (p=0.371) or GGT (p=0.528) between the two groups. Novelty: This study presents a direct comparison of ALP and GGT measurements across two alcohol-consumption-duration groups in adolescents. Implications: The findings provide laboratory data regarding ALP and GGT measurements in adolescent alcohol consumers with different consumption durations.

Key Findings

Thirty participants were divided equally by consumption duration.

Mean ALP values rose from 186.8 to 201.1 U/L.

Mean GGT values rose from 16.4 to 18.4 U/L.

Keywords : Alkaline Phosphatase, Gamma-glutamyltransferase, Alcohol Consumption, Adolescents, Liver Enzymes

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